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This correlation persisted in multivariable analysis: odds ratio of 2.4 (95% confidence interval = 1.2 to 4.6, P = 0.01) for thromboembolic event, and odds ratio of 5.0 (95% confidence interval = 1.9 to 12.8, P ), but not anemia alone, was correlated with poor 1-month outcomes in patients with TBI [40].

Brain dysfunction is frequent during sepsis and is associated with increased mortality and long-term cognitive dysfunction.

Acute brain injury, whatever its cause, is associated with considerable short-term and long-term morbidity and mortality.

However, use of these potential interventions in human randomized controlled studies has generally given disappointing results.

Risks associated with reperfusion therapies, apart from failure to reperfuse, include intracerebral hemorrhage (ICH), ischemia–reperfusion injury and catheterization complications.

A large-scale randomized trial indicated that intravenous recombinant tissue plasminogen activator (alteplase) administered within 3 hours of ischemic stroke onset was associated with significantly improved functional outcomes when compared with placebo, but with an increased risk of ICH [8].

Decompressive craniectomy is sometimes used in TBI patients with raised intracranial pressure (ICP) not responding to first-tier intensive care and neurosurgical therapies.

A randomized controlled trial, however, found that those randomized to decompressive craniectomy had decreased ICP and length of ICU stay but more unfavorable outcomes as determined by the Extended Glasgow Outcome Scale at 6 months after injury [20].

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